Gastric-resistant isoniazid pellets reduced degradation of rifampicin in acidic medium
نویسندگان
چکیده
منابع مشابه
Formulation and Evaluation Ofenteric Coated Pellets of Rifampicin and Isoniazid with Improved Rifampicin Stability
Objective: The aim of the present study is to formulate and evaluate enteric coated pellets of Rifampicin and Isoniazid with improved Rifampicin stability in invitro conditions. Methodology: Two different capsule formulations of these drugs were prepared. Formulation-I contains immediate release uncoated pellets of Rifampicin and Isoniazid. Formulation-IIcontains immediate release enteric coate...
متن کاملIsoniazid- and rifampicin-induced thrombocytopenia
Treatment of tuberculosis has many side effects. Thrombocytopenia is a serious side effect of such treatment and occurs mostly due to rifampicin (RIF). There are very few reported cases of thrombocytopenia due to isoniazid (INH). An 18-year-old female patient was diagnosed with smear-positive pulmonary tuberculosis. A four-drug regimen [INH, RIF, ethambutol (EMB), and pyrazinamide (PZA)] was gi...
متن کاملFormulation and Evaluation of Multiparticulate Systems of Rifampicin and Isoniazid with Improved Rifampicin Stability
Methods: Two different capsule formulations of these drugs were prepared. Formulation-I contains immediate release uncoated pellets of Rifampicin and Isoniazid. Formulation-IIcontains immediate release pellets of Rifampicin and enteric coated pellets of Isoniazid. These pellets were evaluated for various physicochemical parameters. Enteric coating was mainly done to prevent the release of Isoni...
متن کاملMolecular characterization of rifampicin- and isoniazid-resistant Mycobacterium tuberculosis strains isolated in Kazakhstan.
Kazakhstan is one of the 14 countries with a high rate of morbidity due to multidrug-resistant tuberculosis (MDR TB) in WHO European region. The aim of our study was to characterize mutations associated with drug resistance to rifampicin and isoniazid in Mycobacterium tuberculosis isolates from Kazakhstan. M. tuberculosis strains were isolated from TB patients in different regions of Kazakhstan...
متن کاملLine probe assay for detection of rifampicin and isoniazid resistant tuberculosis in Pakistan.
OBJECTIVE To assess the efficacy of a line-probe assay delta (LiPA) as rapid diagnostic test for early detection of drug-resistant tuberculosis compared to conventional susceptibility methods in Pakistan. METHODS Resistance to rifampicin (RIF) and isoniazid (INH) in 108 smear-positive pulmonary tuberculosis samples was detected using a line-probe assay [GenoType MTBDRplus (Hain Lifescience, G...
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ژورنال
عنوان ژورنال: Brazilian Journal of Pharmaceutical Sciences
سال: 2014
ISSN: 1984-8250
DOI: 10.1590/s1984-82502014000400010